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CTOT Peer-Reviewed Publications

Year Funding Source Publication Citation Details PMID/PMCID
2007 Heeger Grant Pretransplant cellular alloimmunity as assessed by a panel of reactive T cells assay correlates with acute renal graft rejection Poggio ED, Augustine JJ, Clemente M, Danzig JM, Volokh N, Zand MS, Hricik DE, Heeger PS. Transplantation. 2007 Apr 15; 83(7): 847-52.
2008 Heeger Grant Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury Keslar K, Rodriguez ER, Tan CD, Starling RC, Heeger PS. Transplantation. 2008 Nov 15; 86(9): 1319-21. PMC2656139
2008 Heeger Grant Preferential benefit of antibody induction therapy in kidney recipients with high pretransplant frequencies of donor-reactive interferon-gamma enzyme-linked immunosorbent spots Augustine JJ, Poggio ED, Heeger PS, Hricik, DE. Transplantation. 2008 Aug 27; 86(4): 529-34. PMC4108983
2008 Heeger Grant T-cell immune monitoring in organ transplantation Dinavahi R, Heeger PS. Curr Opin Organ Transplant. 2008 Aug; 13(4): 419-24. PMC2771347
2008 Heeger Grant Cytotoxicity and antibody binding by flow cytometry: a single assay to simultaneously assess two parameters Saw CL, Bray RA, Gebel HM. Cytometry B Clin Cytom. 2008 Sep; 74(5): 287-94.
2009 Heeger Grant Prognosis on chronic dobutamine or milrinone infusions for stage D heart failure Gorodeski EZ, Chu EC, Reese JR, Shishehbor MH, Hsich E, Starling RC. Circ Heart Fail. 2009 Jul; 2(4): 320-4.
2009 Shaked Grant Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure Putt ME, Hannenhalli S, Lu Y, Haines P, Chandrupatla HR, Morrisey EE, Marqulies KB, Cappola TP. Circ Cardiovasc Genet. 2009 Jun; 2(3): 212-9. PMC3157251
2009 Shaked Grant Plasma cytokines and chemokines in primary graft dysfunction post-lung transplantation Hoffman SA, Wang L, Shah CV, Ahya VN, Pochettino A, Olthoff K, Shaked A, Willie K, Lama VN, Milstone A, Ware LB, Orens J, Weinacker A, Demissie E, Bellamy S, Kawut SM, Hancock WW, Christie JD, Lung Transplant Outcomes Group. Am J Transplant. 2009 Feb; 9(2): 389-96. PMC2821938
2009 Heeger Grant T-cell immune monitoring in organ transplantation Dinavahi R, Heeger PS. Transplantation. 2009 Nov; 27(88): 1157-8. PMC4082955
2010 Heeger Grant 25-OH-vitamin D deficiency and cellular alloimmunity as measured by panel of reactive T cell testing in dialysis patients Sawinski D, Uribarri J, Peace D, Yao T, Wauhop P, Trzcinka P, Ostrow K, Poggio ED, Heeger PS. Am J Transplant. 2010 Oct; 10(10): 2287-95. PMC2948589
2010 Heeger Grant Gazing into a crystal ball to predict kidney transplant outcome Schroppel B, Heeger PS. Mount J Clin Invest. 2010 Jun 1; 120(6): 1803-6. PMC2877963
2010 Heeger Grant Effects of influenza immunization on humoral and cellular alloreactivity in humans Danziger-Isakov L, Cherkassky L, Siegel H, McManamon M, Kramer K, Budev M, Sawinski D, Augustine JJ, Hricik DE, Fairchild R, Heeger PS, Poggio ED. Transplantation. 2010 Apr 15; 89(7): 838-44. PMC3590069
2010 Shaked Grant Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors Olthoff KM, Kulik L, Samstein B, Kaminski M, Abecassis M, Emond J, Shaked A, Christie JD. Liver Transpl. 2010 Aug; 16(8): 943-9.
2010 Larsen Grant Low-density array PCR analysis of reperfusion biopsies: an adjunct to histological analysis Cravedi P, Maggiore U, Mannon RB. Nephrol Dial Transplant. 2010 Dec; 25(12): 4077-86. PMC3108365
2010 ARRA Grant Antibodies Reactive to Non-HLA Antigens in Transplant Glomerulopathy Rajani Dinavahi, Ajish George, Anne Tretin, Enver Akalin, Scott Ames, Jonathan S. Bromberg, Graciela DeBoccardo, Nicholas DiPaola, Susan M. Lerner, Anita Mehrotra, Barbara T. Murphy, Tibor Nadasdy, Estela Paz Artal, Daniel R. Salomon, Bernd Schröppel, Vinita Sehgal, Ravi Sachidanandam and Peter S. Heeger. Journal of the American Society of Nephrology. 2011 June; 22(6): 1168-1178. PMC3103737
2010 Heeger Grant Immune reconstitution following rabbit antithymocyte globulin Gurkan S, Luan Y, Dhillon N, Allam SR, Montague T, Bromberg JS, Ames S, Lerner S, Ebcioglu Z, Nair V, Dinavahi R, Sehgal V, Heeger P, Schroppel B, Murphy B. Am J Transplant. 2010 Sep; 10(9): 2132-2141. PMC4076707
2011 Chandraker Grant Effect of biologic agents on regulatory T cells De Serres SA, Yeung MY, Mfarrej BG, Najafian N. Transplant Rev (Orlando). 2011 Jul; 25(3): 110-6.
2011 Chandraker Grant Monocyte-secreted inflammatory cytokines are associated with transplant glomerulopathy in renal allograft recipients De Serres SA, Vadivel N, Mfarrej BG, Grafals M, DeJoseph M, Dyer C, Magee CN, Chandraker A, Gallon LG, Najafian N. Transplantation. 2011 Mar 15; 91(5): 552-9.
2011 ARRA Grant Antibody reactive to non-HLA antigens in kidney glomerulopathy Dinavahi R, George A, Tretin A, Akalin E, Ames S, Bromberg JS, Deboccardo G, Dipaola N, Lerner SM, Mehrotra A, Murphy BT, Nadasdy T, Paz-Artal E, Salomon DR, Schroppel B, Sehgal V, Sachidanandam R, Heeger PS. J Am Soc Nephrol. 2011 Jun; 22(6): 1168-78. PMC3103737
2011 Chandraker Grant Morphometric and visual evaluation of fibrosis in renal biopsies Farris AB, Adams CD, Brousaides N, Della Pelle PA, Collins AB, Moradi E, Smith RN, Grimm PC, Colvin RB. J Am Soc Nephrol. 2011 Jan; 22(1): 176-86. PMC3014046
2011 Abecassis Grant Clinical and plasma proteomic markers correlating with chronic kidney disease after liver transplantation Levitsky J, Salomon DR, Abecassis M, Langfelder P, Horvath S, Friedewald J, Wang E, Kurian SM, Mondala T, Gil S, McDade R, Ballard K, Gallon L. Am J Transplant. 2011 Sep; 11(9): 1972-8. PMC3166389
2011 CTOT-01 Anticardiac Myosin Immunity and Chronic Allograft Vasculopathy in Heart Transplant Recipients S. Kalache, R. Dinavahi, S. Pinney, A Mehrotra, M. Cunningham, P. Heeger. Journal of Immunology. 2011 July 15; 187(2): 1023-1030. PMC3131454
2012 Abecassis Grant The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys. Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA. Proceedings of the National Academy of Science U S A. 2012 April 17; 109(16): 6036-6041 PMC3341022
2012 Larsen Grant A case of late kidney allograft failure: a clinical pathological conference from American Society of Nephrology Kidney Week 2011. Randhawa P, Mannon RB. Clin J Am Soc Nephrol. 2012 Nov; 7(11): 1884-9 PMC3488950
2012 Shaked Grant Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation. Friedman BH, Wolf JH, Wang L, Putt ME, Shaked A, Christie JD, Hancock WW, Olthoff KM. Liver Transpl. 2012 Feb; 18(2): 166-76 PMC3266982
2012 Sayegh Grant Renal interstitial fibrosis: mechanisms and evaluation. Farris AB, Colvin RB. Curr Opin Nephrol Hypertens. 2012 May; 21(3): 289-300 PMC3354760
2012 Heeger Grant Effect of high-dose intravenous immunoglobulin on anti-HLA antibodies in sensitized kidney transplant candidates. Nair V, Sawinski D, Akalin E, Friedlander R, Ebcioglu Z, Sehgal V, Dinavahi R, Khaim R, Ames S, Lerner S, Murphy B, Bromberg JS, Heeger PS, Schröppel B. Clin Transplant. 2012 May-Jun; 26(3): E261-8 PMC3381356
2012 Heeger Grant Protein and peptide biomarkers in organ transplantation. Sigdel TK, Gao X, Sarwal MM. Biomark Med. 2012 Jun; 6(3): 259-71
2012 Heeger Grant Sequestration and Suppression of Anti-HLA Antibodies by a Failed Kidney Allograft. Vinay Nair and Peter S. Heeger. Clin J Am Soc Nephrol. 2012 Aug; 7(8): 1209-10
2012 Chandraker Grant Derivation and validation of a cytokine-based assay to screen for acute rejection in renal transplant recipients. De Serres SA, Mfarrej BG, Grafals M, Riella LV, Magee CN, Yeung MY, Dyer C, Ahmad U, Chandraker A, Najafian N. Clin J Am Soc Nephrol. 2012 Jun; 7(6): 1018-25 PMC3362312
2012 Chandraker Grant Ex vivo expansion of human Tregs by rabbit ATG is dependent on intact STAT3-signaling in CD4+ T cells and requires the presence of monocytes. Boenisch O, Lopez M, Elyaman W, Magee CN, Ahmad U, Najafian N. Am J Transplant. 2012 Apr; 12(4): 856-66 PMC3777828
2012 Chandraker Grant Immune profile of pediatric renal transplant recipients following alemtuzumab induction. De Serres SA, Mfarrej BG, Magee CN, Benitez F, Ashoor I, Sayegh MH, Harmon WE, Najafian N. J Am Soc Nephrol. 2012 Jan; 23(2): 174-82 PMC3269923
2012 Chandraker Grant Immunologic monitoring in transplantation revisited. Cravedi P, Heeger PS. Curr Opin Organ Transplant. 2012 Feb; 17(1): 26-32 PMC3285386
2013 CTOT-03 Gene Set Enrichment Analysis Identifies Key Innate Immune Pathways in Primary Graft Dysfunction After Lung Transplantation E. Cantu1, D. J. Lederer, K. Meyer, K. Milewski, Y. Suzuki, R. J. Shah, J. M. Diamond, N. J. Meyer, J. W. Tobias, D. A. Baldwin, V. M. Van Deerlin, K. M. Olthoff, A. Shaked, J. D. Christie. American Journal of Transplantation. 2013 Jul; 13(7):1898-904. PMC3954988
2013 ARRA Cellular Working Group Standardization and Cross Validation of Alloreactive IFN? ELISPOT Assays Within the Clinical Trials in Organ Transplantation Consortium Ashoor I, Najafian N, Korin Y, Reed EF, Mohanakumar T, Ikle D, Heeger PS, Lin M. American Journal of Transplantation. 2013 Jul; 13(7):1871-9. PMC3839289
2013 ARRA Molecular Working Group Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL. American Journal of Transplantation. 2013 Jul; 13(7):1891-7. PMC3781926
2013 ARRA Antibody Working Group Comprehensive Assessment and Standardization of Solid Phase Multiplex-Bead Arrays for the Detection of Antibodies to HLA Reed EF, Rao P, Zhang Z, Gebel H, Bray RA, Guleria I, Lunz J, Mohanakumar T, Nickerson P, Tambur AR, Zeevi A, Heeger PS, Gjertson D. American Journal of Transplantation. 2013 Jul; 13(7):1859-70 PMC3967448
2013 CTOT-04 Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts Manikkam Suthanthiran, M.D., Joseph E. Schwartz, Ph.D., Ruchuang Ding, M.D., Michael Abecassis, M.D., Darshana Dadhania, M.D., Benjamin Samstein, M.D., Stuart J. Knechtle, M.D., John Friedewald, M.D., Yolanda T. Becker, M.D., Vijay K. Sharma, Ph.D., Nikki M. Williams, B.S., Christina S. Chang, B.S., Christine Hoang, B.S., Thangamani Muthukumar, M.D., Phyllis August, M.D., M.P.H., Karen S. Keslar, M.S., Robert L. Fairchild, Ph.D., Donald E. Hricik, M.D., Peter S. Heeger, M.D., Leiya Han, M.D., M.P.H., Jun Liu, Ph.D., Michael Riggs, Ph.D., M.P.H., David N. Ikle, Ph.D., Nancy D. Bridges, M.D., and Abraham Shaked, M.D., Ph.D. for the Clinical Trials in Organ Transplantation 04 (CTOT-04) Study Investigators. New England Journal of Medicine 2013 Jul 4; 369(1):20-31. PMC3786188
2013 CTOT-01 Multicenter Validation of Urinary CXCL9 as a Risk-Stratifying Biomarker for Kidney Transplant Injury D. E. Hricik, P. Nickerson, R. N. Formica, E. D. Poggio, D. Rush, K. A. Newell, J. Goebel, I. W. Gibson, R. L. Fairchild, M. Riggs, K. Spain, D. Ikle, N. D. Bridges, P. S. Heeger, for the CTOT-01 consortium. American Journal of Transplantation, 22 AUG 2013, DOI: 10.1111/ajt.12426. PMC3959786
2013 Heeger Grant Transplantation: Complementing donor-specific antibody testing. Tinckam KJ, Heeger PS. Nat Rev Nephrol. 2013 Dec; 9(12): 713-4 PMC4090765
2013 Heeger & Chandraker Grants Transplantation: A new molecular approach to the diagnosis of acute rejection. Anil Chandraker & Terry B. Strom. Nat Rev Nephrol. 2013 Nov; 9(11): 631-32
2013 Heeger Grant Moving beyond HLA: a review of nHLA antibodies in organ transplantation Sigdel TK, Sarwal MM. Hum Immunol. 2013 Nov; 74(11): 1486-90 PMC5221517
2013 Heeger Grant Discovery and customized validation of antibody targets by protein arrays and indirect ELISA Sigdel TK, Sarwal MM. Methods Mol Biol. 2013; 1034: 373-84 PMC4476239
2013 Heeger Grant Effects of cellular sensitization and donor age on acute rejection and graft function after deceased-donor kidney transplantation Hricik DE, Poggio ED, Woodside KJ, Sarabu N, Sanchez EQ, Schulak JA, Padiyar A, Heeger PS, Augustine JJ. Transplantation. 2013 May 27; 95(10): 1254-8 PMC4076048
2013 Heeger Grant Immunosuppressive effects of the traditional Chinese herb Qu Mai on human alloreactive T cells Reid-Adam J, Yang N, Song Y, Cravedi P, Li XM, Heeger P. Am J Transplant. 2013 May; 13(5): 1159-67 PMC3640757
2013 Abecassis Grant MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation differentiation and development Podshivalova K, Solomon DR. Crit Rev Immunol. 2013; 33(5): 435-76 PMC4185288
2013 Abecassis Grant Genomic biomarkers correlate with HLA-identical renal transplant tolerance. Leventhal JR, Mathew JM, Salomon, DR, Kurian SM, Suthanthiran M, Tambur A, Friedewald J, Gallon L, Charette J, Levitsky J, Kanwar Y, Abecassis M, Miller J. J Am Soc Nephro. 2013 Sep; 24(9): 1376-85 PMC3752953
2013 Abecassis Grant Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients. Leventhal JR, Mathew JM, Abecassis M, Tambur A, Leventhal J, Chandrasekaran D, Herrera N, Al-Saden P, Gallon L, Abdul-Nabi A, Yang GY, Kurian SM, Salomon DR, Miller J. Hepatology. 2013 Jan; 57(1): 239-48 PMC3334454
2013 Shaked Grant Primary graft dysfunction. Suzuki Y, Cantu E, Christie JD. Semin Respir Crit Care Med. 2013 Jan; 34(3): 305-319 PMC3968688
2014 ARRA Proteomics Working Group Optimization for peptide sample preparation for urine peptidomics Sigdel TK, Nicora CD, Hsieh SC, Dai H, Qian WJ, Camp DG 2nd, Sarwal MM. Clin Proteomics. 2014 Feb 25;11(1):7. PMC3944950
2014 ARRA Infectious Disease Working Group Multicenter comparison of laboratory performance in cytomegalovirus and Epistein-Barr virus viral load testing using international standards Rychert J, Danziger-Isakov L, Yen-Lieberman B, Storch G, Buller R, Sweet SC, Mehta AK, Cheeseman JA, Heeger P, Rosenberg ES, Fishman JA. Clin Transplant. 2014 Dec; 28(12): 1416-23 PMC4481866
2014 Heeger Grant Effect of cholecalciferol supplementation in inflammation and cellular alloimmunity in hemodialysis patients: data from a randomized controlled pilot trial Li L, Lin M, Krassilnikova M, Ostrow K, Bader A, Radbill B, Uribarri J, Tokita J, Leisman S, Lapsia V, Albrecht RA, Garcia-Sastre A, Branch AD, Heeger PS, Mehrotra A. PLoS One. 2014 Oct 8; 9(10): e109998 PMC4190314
2014 Vincenti Grant A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. Delville M, Sidgel TK, Wei C, Li J, Hsieh SC, Fornoni A, Burke GW, Bruneval P, Naesens M, Jackson A, Alachkar N, Canaud G, Legendre C, Anglicheau D, Reiser J, Sarwal MM. Sci Transl Med. 2014 Oct 1; 6(256) PMC4394366
2014 CTOT-04 Urinary cell mRNA profiles predictive of human kidney allograft status. Lee JR, Muthukumar T, Dadhania D, Ding R, Sharma VK, Schwartz JE, Suthanthiran M. Immunol Rev. 2014 Mar; 258(1): 218-40 PMC3947569
2014 Heeger Grant Molecular monitoring of alloimmune-mediated injury in kidney transplant patients. Traitanon O, Poggio ED, Fairchild RL. Curr Opin Nephrol Hypertens. 2014 Nov; 23(6): 625-30
2014 Heeger Grant Immunosuppressive effects of erythropoietin on human alloreactive T cells Cravedi P, Manrique J, Hanlon KE, Reid-Adam J, Brody J, Prathuangsuk P, Mehrotra A, Heeger PS. J Am Soc Nephrol. 2014 Sep; 25(9): 2003-15 PMC4147979
2014 Heeger Grant Antibody-mediated graft injury: complement-dependent and complement-independent mechanisms. Valenzuela NM, McNamara JT, Reed EF. Curr Opin Organ Transplant. 2014 Feb; 19(1): 33-40 PMC4080796
2014 Chandraker Grant Glomerular inflammation correlates with endothelial injury and with IL-6 and IL-1ß secretion in the peripheral blood Batal I, De Serres SA, Mfarrej BG, Grafals M, Pinkus GS, Kalra A, Weins A, Bijol V, Rennke HG, Guleria I, Abdi R, Chandraker A, Najafian N. Transplantation. 2014 May 27; 97(10): 1034-42
2014 Abecassis Grant Molecular classifiers for acute kidney transplant rejection in peripheral blood by whole genome expression profiling Kurian SM, Williams AN, Gelbart T, Campbell D, Mondala TS, Head SR, Horvath S, Gaber L, Thompson R, Whisenant T, Lin W, Langfelder P, Robison EH, Schaffer RL, Fisher JS, Friedewald J, Flechner SM, Chan LK, Wiseman AC, Shidban H, Mendez R, Heilman R, Abecassis MM, Marsh CL, Salomon DR. Am J Transplant. 2014 May; 14(5): 1164-72 PMC4439107
2014 Abecassis Grant Library construction for next-generation sequencing: overviews and challenges Head SR, Homori HK, LaMere SA, Whisenant T, Van Nieuwerburgh F, Salomon DR, Ordoukhanian P. Biotechniques. 2014 Feb 1; 56(2): 61-4 PMC4351865
2014 Shaked Grant Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice. Wolf JH, Bhatti TR, Fouraschen S, Chakravorty S, Wang L, Kurian S, Salomon D, Olthoff KM, Hancock WW, Levine MH. Liver Transpl. 2014 Mar; 20(3): 376-85 PMC3947447
2014 Heeger Grant B Cells and Kidney Transplantation: Beyond Antibodies. Anita Mehrotra and Peter S. Heeger. J Am Soc Nephrol. 2014 Jul; 25(7): 1373-1374 PMC4073443
2015 CTOT-01 Interferon Gamma ELISPOT Testing as a Risk-Stratifying Biomarker for Kidney Transplant Injury: Results From the CTOT-01 Multicenter Study Hricik, D. E., Augustine, J., Nickerson, P., Formica, R. N., Poggio, E. D., Rush, D., Newell, K. A., Goebel, J., Gibson, I. W., Fairchild, R. L., Spain, K., Iklé, D., Bridges, N. D., Heeger, P. S. for the CTOT-01 consortium. American Journal of Transplantation, 30 JUL 2015, DOI: 10.1111/ajt.13401
2015 CTOT-05 Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study Starling RC, Stehlik J, Baran D, Armstrong B, Stone JR, Iklé, D, Morrison Y, Bridges, ND, Puthethi P, Strom TB, Bhasin M, Guleria I, Chandraker A, Sayegh M, Daly KP, Briscoe DM, Heeger, PS, and the CTOT-05 consortium. American Journal of Transplantation, 10 AUG 2015, DOI: 10.1111/ajt.13422
2015 CTOT-04 Urine Metabolite Profiles Predictive of Human Kidney Allograft Status Karsten Suhre, Joseph E Schwartz, Vijay Sharma, Qiuying Chen, John R Lee, Thangamanai, Darshana M Dadhania, Ruchuange Ding, David Ikle, Nancy D Bridges, Nikki M Williams, Gavi Kastenmuller, Edward D Karoly, Robert P Mohney, Michael Abecassis, John Friedewald, Stuart J Knechtle, Yolanda T Becker, Benjamin Samstein, Abraham Shaked, Steven S Gross, Manikkam Suthanthiran. J Am Soc Nephrol. 2015 Jun 5. pii: ASN.2015010107.
2015 CTOT-09 Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients Donald E Hricik, Richard N Formica, Peter Nickerson, David Rush, Robert L Fairchild, Emilio Poggio, Ian W Gibson, Chris Wiebe, Kathryn Tinckam, Suphamai Bunnaprist, Milagros Samaniego-Picota, Daniel C Brennan, Bernd Schroppel, Osama Gaber, Brian Armstrong, David Ikle, Helena Diop, Nancy D Bridges, Peter S Heeger (for CTOT-09 consortium). J Am Soc Nephrol. 2015 Dec;26(12):3114-22. doi: 10.1681/ASN.2014121234. Epub 2015 Apr 29.
2015 Abecassis & Shaked Grants Genomic profiles and predictors of early allograft dysfunction after human liver transplanation Kurian SM, Fouraschen SM, Langfelder P, Horvath S, Shaked A, Salomon DR, Olthoff KM. Am J Transplant. 2015 Jun; 15(6): 1605-14
2015 Shaked Grant CTOT-03 Samples Design and Implementation of the International Genetics and Translational Research in Transplantation Network International Genetics & Translational Research in Transplantation Network (iGeneTRAiN). Transplantation. 2015 Nov; 99(11): 2401-12 PMC4623847
2015 Chandraker Grant Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival Batal I, De Serres SA, Safa K, Bijol V, Ueno T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A. J Am Soc Nephrol. 2015 Dec; 26(12): 3102-13 PMC4657833
2015 Larsen Grant Genomic and proteomic fingerprints of acute rejection in peripheral blood and urine Ong S, Mannon RB. Transplant Rev (Orlando). 2015 Apr; 29(2): 60-7 PMC4397134
2015 Larsen Grant The Cost of Transplant Immunosuppressant Therapy: Is This Sustainable? Alexandra James and Roslyn B. Mannon. Curr Transplant Rep. 2015 Jun 1; 2(2): 113-121 PMC4520417
2015 Heeger Grant Peripheral natural killer cell and allo-stimulated T-cell function in kidney transplant recipients associate with cancer risk and immunosuppression-related complications. Hope CM, Troelnikov A, Hanf W, Jesudason S, Coates PT, Heeger PS, Carroll RP. Kidney Itn. 2015 Dec; 88(6): 1374-1382 PMC4950672
2015 Shaked Grant Concept and designs of a genome-wide association genotyping array tailored for transplantation-specific studies. Li YR, van Setten J, Verma SS, Shaked A, Keating BJ, et al. Genome Med. 2015 Oct 1; 7:90 PMC4589899
2016 CTOT Supported Polyfunctional T-cell signatures to predict protection from cytomegalovirus after lung transplantation. Snyder LD, Chan C, Kwon K, Yi JS, Martissa JA, Copeland CA, Osborne RJ, Sparks SD, Palmer SM, Weinhold JK. Am J Respir Crit Care Med. 2016 Jan 1; 193(1): 78-85 PMC4731614
2016 CTOT-04 Urine metabolite profiles predictive of human kidney allograft status. Suhre K, Schwartz JE, Sharma VK, Chen Q, Lee JR, Muthukumar T, Dadhania DM, Ding R, Ikle DN, Bridges ND, Williams NM, Katenmuller G, Karoly ED, Mohney RP, Abecassis M, Friedewald J, Knechtle SJ, Becker YT, Samstein B, Shaked A, Gross SS, Suthanthiran M. J Am Soc Nephrol. 2016 Feb; 27(2): 626-36 PMC4731125
2016 Larsen Grant Anti-Leukocyte Function-Associated Antigen 1 Therapy in a Nonhuman Primate Renal Transplant Model of Costimulation Blockade-Resistant Rejection Anderson DJ, Lo DJ, Leopardi F, Song M, Turgeon NA, Strobert EA, Jenkins JB, Wang R, Reimann KA, Larsen CP, Kirk AD. Am J Transplant. 2016 May; 16(5): 1456-64 PMC5066576
2016 Palmer Grant Validation and Refinement of Chronic Lung Allograft Dysfunction Phenotypes in Bilateral and Single Lung Recipients DerHovanessian A, Todd JL, Zhang A, Li N, Mayalall A, Finlen Copeland CA, Shino M, Pavlisko EN, Wallas WD, Gregson A, Ross DJ, Saggar R, Lynch JP 3rd, Belperio J, Snyder LD, Palmer SM, Weigt SS. Ann Am Thorac Soc. 2016 May; 13(5): 627-35 PMC5018895
2016 Palmer Grant Staging of Bilateral Lung Transplantation for High-Risk Patients with Interstitial Lung Disease: One Lung at a Time Hartwig MG, Ganapathi AM, Osho AA, Hirji SA, Englum BR, Speicher PJ, Palmer SM, Davis RD, Snyder LD. Am J Transplant. 2016 Nov; 16(11): 3270-3277 PMC5083210
2016 Palmer Grant The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome DerHovanessian A, Weigt SS, Palchevskiy V, Shino MY, Sayah DM, Gregson AL, Noble PW, Palmer SM, Fishbein MC, Kubak BM, Ardehali A, Ross DJ, Saggar R, Lynch JP 3rd, Elashoff RM, Belperio JA. Am J Transplant. 2016 Feb; 16(2): 640-9 PMC4946573
2016 Heeger Grant Cholesterol efflux capacity of high-density lipoprotein correlates with survival and allograft vasculopathy in cardiac transplant recipients Javaheri A, Molina M, Zamani P, Rodrigues A, Novak E, Chambers S, Stutman P, Maslanek W, Williams M, Lilly SM, Heeger PS, Sayegh MH, Chandraker A, Briscoe DM, Daly KP, Starling R, Ikle D, Christie J, Rame JE, Goldberg LR, Billheimer J, Rader DJ. J Heart Lung Transplant. 2016 Nov; 35(11): 1295-1302 PMC5107129
2017 CTOT Ancillary Study Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction Weigt SS, Wang X, Palchevskiy V, Gregson AL, Patel N, DerHovanessian A, Shino MY, Sayah DM, Birjandi S, Lynch JP 3rd, Saggar R, Ardehali A, Ross DJ, Palmer SM, Elashoff D, Belperio JA. PLoS One. 2017 Jan 19; 12(1) PMC5245825
2017 Palmer Grant Survival Benefit of Lung Transplantation in the Modern Era of Lung Allocation Vock DM, Durheim MT, Tsuang WM, Finlen Copeland CA, Tsiatis AA, Davidian M, Neely ML, Lederer DJ, Palmer SM. Ann Am Thorac Soc. 2017 Feb; 14(2): 172-21 PMC5427730
2017 Heeger Grant Moving Biomarkers toward Clinical Implementation in Kidney Transplantation Menon MC, Murphy B, Heeger PS. J Am Soc Nephrol. 2017 Mar; 28(3): 735-747 PMC5328171
2017 Palmer Grant Danger signals in regulating the immune response to solid organ transplantation Todd JL, Palmer SM. J Clin Invest. 2017 Jun 30; 127(7): 2464-2472 PMC5490743
2017 Palmer Grant Impact of Allograft Injury Time of Onset on the Development of Chronic Lung Allograft Dysfunction After Lung Transplantation Shino MY, Weigt SS, Li N, DerHovanessian A, Sayah DM, Huynh RH, Saggar R, Gregson AL, Ardehali A, Ross DJ, Lynch JP 3rd, Elashoff RM, Belperio JA. Am J Transplant. 2017 May; 17(5):1294-1303 PMC5368037
2017 ARRA ID WG Discrepant Serologic Assays for Pneumococcus in Renal Transplant Recipients Fishman JA, Iklé DN, Wilkinson RA. Transpl Itn. 2017 Jul; 30(7): 689-694 PMC5513779
2017 CTOT-03 Peripheral Blood Gene Expression Changes Associated With Primary Graft Dysfunction After Lung Transplantation Diamond JM, Cantu E, Porteous MK, Suzuki Y, Meyer KC, Lederer DJ, Milewski RK, Arcasoy S, D'Ovidio F, Bacchetta M, Sonett JR, Singh G, Costa J, Tobias JW, Rodriguez H, Van Derrlin VM, Olthoff KM, Shaked A, Chang BL, Christie JD, Clinical Trials in Organ Transplantation (CTOT)-03 Investigators. Am J Transplant. 2017 Jul; 17(7): 1770-1777 PMC5489369
2017 CTOT-12/ITN524ST B Cell Receptor Genes Associated With Tolerance Identify a Cohort of Immunosuppressed Patients With Improved Renal Allograft Graft Function Asare A, Kanaparthi S, Lim N, Phippard D, Vincenti F, Friedewald J, Pavlakis M, Poggio E, Heeger P, Mannon R, Burrell BE, Morrison Y, Bridges N, Sanz I, Chandraker A, Newell KA, Turka LA. Am J Transplant. 2017 Oct; 17(10): 2627-2639 PMC5620117
2017 CTOT-10 Lessons learned: early termination of a randomized trial of calcineurin inhibitor and corticosteroid avoidance using Belatacept Newell KA, Mehta AK, Larsen CP, Stock PG, Farris AB, Mehta SG, Iklé D, Armstrong B, Morrison Y, Bridges N, Robien M, Mannon RB. Am J Transplant. 2017 Oct; 17(10): 2713-2719 PMC5623170
2017 CTOT Supported Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction Weigt SS, Palchevskiy V, Belperio JA. J Clin Invest. 2017 Jun 1; 127(6): 2022-2029 PMC5451233
2017 Heeger Grant Rapid Biolayer Interferometry Measurements of Urinary CXCL9 to Detect Cellular Inflitrates Noninvasively After Kidney Transplantation Gandolfini I, Harris C, Abecassis M, Anderson L, Bestard O, Comai G, Cravedi P, Cremaschi E, Duty JA, Florman S, Friedewald J, La Manna G, Maggiore U, Moran T, Piotti G, Purroy C, Jarque M, Nair V, Shapiro R, Reid-Adam J, Heeger PS. Kidney Int Rep. 2017 Jun 21; 2(6): 1186-1193 PMC5733675
2017 Vincenti Grant Transplant trials with Tregs: perils and promises Tang Q, Vincenti F. J Clin Invest. 2017 Jun 30; 127(7): 2505-2512 PMC5490750
2017 Heeger Grant Posttransplant peripheral blood donor-specific interferon-γ enzyme-linked immune spot assay differentiates risk of subclinical rejection and de novo donor-specific alloantibodies in kidney transplant recipients Crespo E, Cravedi P, Martorell J, Luque S, Melilli E, Cruzado JM, Jarque M, Meneghini M, Manonelles A, Donadei C, Lloberas N, Goma M, Grinyo JM, Heeger P, Bestard O. Kidney Int. 2017 Jul; 92(1): 201-213 PMC5930006
2017 Palmer Grant Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction Belperio J, Palmer SM, Weigt SS. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3): S242-S246 PMC5711338
2017 Palmer Grant Contemporary Issues in Lung Transplant Allocation Practices Tsuang WM. Curr Transplant Rep. 2017 Sep; 4(3): 238-242 PMC5609823
2017 Vincenti Grant Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA< Vincenti F. Am J Transplant. 2018 Nov; 17(11): 2945-2954 PMC5662482
2018 Palmer Grant The Prognostic Importance of Bronchoalveolar Lavage Fluid CXCL9 During Minimal Acute Rejection on the Risk of Chronic Lung Allograft Dysfunction Shino MY, Weigt SS, Li N, DerHovanessian A, Sayah DM, Saggar R, Huynh RH, Gregson AL, Ardehali A, Ross DJ, Lynch JP Rd, Elashoff RM, Belperio JA. Am J Transplant. 2018 Jan; 18(1): 136-144 PMC5739954
2018 CTOT-17 Analysis of Biomarkers Within the Initial 2 Years Posttransplant and 5-Year Kidney Transplant Outcomes: Results from Clinical Trials in Organ Transplantation-17 Faddoul G, Nadkarni GN, Bridges ND, Goebel J, Hricik DE, Formica R, Menon MC, Morrison Y, Murphy B, Newell K, Nickerson P, Poggio ED, Rush D, Heeger PS< CTOT-17 Consortium. Transplantation. 2018 Apr; 102(4): 673-680 PMC6018026
2018 Palmer Grant Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft Weigt SS, Wang X, Palchevskiy V, Patel N, DerHovanessian A, Shino MY, Sayah DM, Lynch JP 3rd, Saggar R, Ross DJ, Kubak BM, Ardehali A, Palmer S, Husain S, Belperio JA. Transplantation. 2018 Jun; 102(6): 986-993 PMC5962368
2018 CTOT-08 Development and clinical validity of a novel blood-based molecular biomarker for subclinical acute rejection following kidney transplant Friedewald JJ, Kurian SM, Heilman RL, Whisenant TC, Poggio ED, Marsh C, Baliga P, Odim J, Brown MM, Ikle DN, Armstrong BD, Charette JI, Brietigam SS, Sustento-Reodica N, Zhao L, Kandpal M, Salomon DR, Abecassis MM, Clinical Trials in Organ Transplantation 08 (CTOT-08). Am J Transplant. 2018 Jul; 19(1): 98-109 PMC6387870
2018 Heeger Grant P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes D'Addio F, Vergani A, Potena L, Maestroni A, Usuelli V, Ben Nasr M, Bassi R, Tezza S, Dellepiane S, El Essaway B, Isacone M, Iacovoni A, Borgese L, Liu K, Visner G, Dhe-Paganon S, Corradi D, Abdi R, Starling RC, Folli F, Zuccotti GV, Sayegh MH, Heeger PS, Chandraker A, Grigioni F, Fiorina P. J Clin Invest. 2018 Aug; 128(8): 3490-3503 PMC6063506
2018 CTOT-18 Early immune biomarkers and intermediate-term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation-18 Stehlik J, Armstrong B, Baran DA, Bridges ND, Chandraker A, Gordon R, De Marco T, Givertz MM, Heroux A, Ikle D, Hunt J, Kfoury AG, Madsen JC, Morrison Y, Feller E, Pinney S, Tripathi S, Heeger PS, Starling RC. Am J Transplant. 2018 Dec PMC30549425
2022 CTOT-20 Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction Shino MY, Todd JL, Neely ML, Kirchner J, Frankel CW, Snyder LD, Pavlisko EN, Fishbein GA, Schaenman JM, Mason K, Kesler K, Martinu T, Singer LG, Tsuang W, Budev M, Shah PD, Reynolds JM, Williams N, Robien MA, Palmer SM, Weigt SS, Belperio JA. Am J Transplant. 2022 Sep;22(9):2169-2179. doi: 10.1111/ajt.17108. Epub 2022 Jun 15. PMID: 35634722

PMCID: PMC9427677
2022 CTOT-20 Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study Pavlisko EN, Neely ML, Kopetskie H, Hwang DM, Farver CF, Wallace WD, Arrossi A, Illei P, Sever ML, Kirchner J, Frankel CW, Snyder LD, Martinu T, Shino MY, Zaffiri L, Williams N, Robien MA, Singer LG, Budev M, Tsuang W, Shah PD, Reynolds JM, Weigt SS, Belperio JA, Palmer SM, Todd JL. Am J Transplant. 2022 Aug 29. doi: 10.1111/ajt.17183. Epub ahead of print. PMID: 36031951
2023 CTOT-19 Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial Hricik DE, Armstrong B, Alhamad T, Brennan DC, Bromberg JS, Bunnapradist S, Chandran S, Fairchild RL, Foley DP, Formica R, Gibson IW, Kesler K, Kim SJ, Mannon RB, Menon MC, Newell KA, Nickerson P, Odim J, Poggio ED, Sung R, Shapiro R, Tinckam K, Vincenti F, Heeger PS. J Am Soc Nephrol. 2023 Jan 1;34(1):145-159. doi: 10.1681/ASN.2022040454. Epub 2022 Oct 4. PMID: 36195441


CTOT Conference Presentations

Year Funding Source Publications
2009 CTOT-01 Early Results From The Clinical Trials In Organ Transplantation (Ctot-01) Trial Identify Noninvasive Markers As Correlates Of 6-Month Renal Allograft Pathology
D Hricik, MD, E Poggio, K Newell, D Rush, P Nickerson, R Formica, E Akalin, J Goebel, R Fairchild, H Gebel, D Ikle and P Heeger and the CTOT-01 Consortium. Abstract presented at the American Transplant Congress, 2009.
2009 CTOT-02
CCTPT-02
Evidence for Immune Activation in Kidney Transplant Recipients Who Develop Post-transplant De Novo Anti-HLA Antibodies: Interim Report of NIH CTOT-02
A Chandraker, B Mfarrej, S De Serres, I Guleria, C Dyer, N Najafian, Y Morrison, N Bridges, D Ikle, W Bennett, A B Cosimi, J Friedewald, A O Gaber, N Goes, B Kaplan, V Kumar,A Olayei, D Norman M Pavlakis, F Weng, P West, F Vincenti and M H Sayegh. Brigham and Women's Hospital & Children’s Hospital Boston, United States. Abstract presented at the American Transplant Congress, 2009.
2009 CTOT-02
CCTPT-02
Evidence for Immune Activation in Kidney Transplant Recipients Who Develop Post-transplant De Novo Anti-HLA Antibodies: Interim Report of NIH CTOT-02
A Chandraker,1S A De Serres, B Mfarrej, I Guleria, C Dyer, N Najafian, Y Morrison, N Bridges, D Ikle, W Bennett, A B Cosimi, J Friedewald, A O Gaber, N Goes, B Kaplan, V Kumar, A Olayei, D Norman, M Pavlakis, F Weng, P West, F Vincenti and M H Sayegh. Transplantation Research Center, Brigham and Women's Hospital, Boston, Harvard Medical School, MA. Poster presented at the American Transplant Congress, 2009.
2009 CTOT-02 Development of De Novo Anti-HLA Antibodies after Transplantation is Associated with Evidence of Systemic Activation of the Immune System: Interim Report of the NIH CTOT-02
A Chandraker, S A De Serres, B Mfarrej, I Guleria, C Dyer, N Najafian, Y Morrison, N Bridges, J Liu, E Norris, W Bennett, A B Cosimi, J Fridewald, A O Gaber, N Goes, B Kaplan, V Kumar, A Olayei, D Norman M Pavlakis, F Weng, P West, F Vincenti, WE Harmon and M H Sayegh.
2010 CTOT-04 Validation of Urinary Cell Biomolecular Markers of Acute Cellular Rejection: A Report from CTOT-4 Trial Investigators.
M. Suthanthiran, R. Ding, V. Sharma, M. Abecassis, D. Dadhania, B. Samstein, S. Knechtle, W. Hancock, J. Schwartz, J. Liu, N. Bridges, A. Shaked and the CTOT-04 Investigators. Abstract presented at the American Transplant Congress, 2010.
2010 CTOT-02
CCTPT-02
Silent development of de novo anti HLA antibodies following transplantation is associated with histological changes in the allograft. Interim report on behalf of the CTOT-02/CCTPT-02 study.
Sacha A De Serres, MD, Bechara G Mfarrej, Indira Guleria, PhD, Nader Najafian, MD, Yvonne R Morrison, Flavio G. Vincenti, MD, William E. Harmon, MD, Mohamed H. Sayegh, MD, FASN and Anil Chandraker, MBChB, FASN. Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA, United States; 2UCSF, San Francisco, CA and 3NIH/NIAID/DAIT, Bethesda, MD. Abstract presented at the American Society for Nephrology Kidney Week, 2010.
2010 CTOT-01 Cellular Or Humoral Sensitization Increases The Risk Of Delayed Graft Function And Acute Rejection In Recipients Of Expanded Criteria Donor Kidneys.
Donald E. Hricik, MD, Joshua J. Augustine, MD, Aparna Padiyar, MD and Peter S. Heeger, MD. University Hospitals Case Medical Center, Cleveland, Ohio, and Mt. Sinai School of Medicine, New York, New York, United States. Abstract presented at ASN Kidney Week, 2010.
2011 CTOT-04 Urinary Cell Messenger RNA Expression Signatures Anticipate Acute Cellular Rejection: A Report from CTOT-04
Suthanthiran M, Ding R, Sharma V, Abecassis M, Dadhania D, Samstein B, Knechtle S, Hancock W, Han L, Schwartz J, Liu J, Bridges N, Shaked A. Abstract presented at the American Transplant Congress, 2011.
2011 CTOT-02
CCTPT-02
Development of circulating anti-HLA antibodies is associated with acute rejection: Interim Analysis of CTOT02
SA De Serres, BG Mfarrej, I Guleria, N Najafian, D Ikle, FG Vincenti WE Harmon, MH Sayegh, and A Chandraker. Abstract presented at ASN Kidney Week, 2011.
2011 CTOT-05 Incidence of Coronary Artery Vasculopathy Has Decreased with Modern Immunosuppression: Insights from Clinical Trials in Organ Transplantation
R.C. Starling, J. Stehlik, S. Nicholls, D. Ikle, A. Chandraker, F. Teresa, D. Baran, K. Wolski, B. Mfarrej, U. Ahmad, M. Sayegh, P. Heeger. Poster presented at the Annual Meeting of the ISHLT, 2011.
2011 CTOT Immune Alteration in Stable Renal Allograft Recipients Treated with Belatacept
PW Thompson; AK Mehta; LA Stempora; J Cheeseman; J Joseph; B Begley; E Ferry; S Thomas; AD Kirk; K Newell; CP Larsen. Poster presented at the Annual Meeting of The Transplantation Society, 2011.
2012 CTOT-02
CCTPT-02
In Vitro C1q Binding is Associated with Acute Rejection Among Renal Transplant Recipients Who Develop Circulating Anti-HLA Antibodies: Preliminary Analysis of the NIH CTOT02.
A Chandraker, S De Serres, U Ahmad, B Mfarrej, I Guleria, N Najafian, D Ikle, H Chin, F G Vincenti, W E Harmon and M H Sayegh. Abstract presented at the American Transplant Congress, 2012.
2012 ARRA Antibody Working Group Validation of the luminex platform to detect and quantify anti-HLA antibodies: Assessment of Manufacture variability by 7 CTOT core laboratories.
E.Reed, P. Rao, Z. Zhang, H. Gebel, I. Guleria, T. Monanakumar, P. Nickerson, A. Tambur, A. Zeevi, D. Gjertson, P. Heeger and the CTOT Core Antibody Testing Laboratories. Abstract presented at the American Transplant Congress, 2012.
2012 ARRA Antibody Working Group Validation of the Luminex platform to detect and quantify anti-HLA antibodies: Consistency in median florescence intensity (MFI) among 7 CTOT core laboratories.
E Reed, P Rao, Z Zhang, H Gebel, I Guleria, T Mohanakumar, P Nickerson, A Tambur, A Zeevi, D Gjertson, P. Heeger and the CTOT Core Antibody Testing Laboratories. Abstract presented at the American Transplant Congress, 2012.
2012 CTOT Comparison of Viral Immunity in Stable Renal Allograft Recipients Treated with Belatacept or Tacrolimus
Yvonne Suessmuth PhD, PW Thompson; C Breeden; B Johnson; R Jones; LA Stempora; J Cheeseman; J Joseph; B Begley; S Thomas; AD Kirk; K Newell; CP Larsen; AK Mehta. Abstract presented at the American Transplant Congress, 2012.
2012 ARRA Antibody Working Group Validation of the Luminex platform to detect and quantify HLA antibodies: Effect of standardizing operation procedures on test variability by CTOT core laboratories
Rao P, Zhang Z., Gebel H., Bray R., Guleria I., Monanakumar T., Nickerson P., Tambur A., Zeevi A., Heeger P., Gjertson D, Reed E and the Clinical Trials in Organ Transplantation Core Antibody Testing Laboratories.
2012 ARRA Antibody Working Group Cross validation of Luminex platforms from two vendors to detect and quantify HLA antibodies using single antigen assay results from 7 CTOT core laboratories.
E.Reed, P. Rao, Z. Zhang, H. Gebel, R. Bray, I. Guleria, T. Monanakumar, P. Nickerson, A. Tambur, A. Zeevi, P. Heeger, D. Gjertson and the Clinical Trials in Organ Transplantation Core Antibody Testing Laboratories. Abstract presented at the Annual Meeting of The Transplantation Society, 2012.
2013 CTOT-10 Comparison of Baseline and Day 28 Post Transplant Renal Allograft Samples for the CTOT-10 Belatacept Study
Y Suessmuth, L A Stempora, B Johnson, J Cheeseman, Y Morrison, N Bridges, D Ikle, S Tomlanovich, P Stock, R Mannon, K Newell, C P Larsen, AK Mehta. Abstract presented at the American Transplant Congress, 2013.
2013 CCTPT-02/ CTOT-02 Children Develop De Novo Anti-HLA Antibodies (Abs) following kidney transplantation at a higher incidence than adults: An Analysis of the NIH CTOT/CCTPT-02 study.
W Harmon, MD, I Guleria, PhD, D Ikle, PhD, B Armstrong, MPH, L Spaneas, RN, MPH, Y Morrison, N Bridges, MD, M Sayegh, MD, A Chandraker, MD. Abstract presented at the American Transplant Congress, 2013.
2013 CTOT-10 Long Term Calcineurin (CNI) and Corticosteroids (CS) Avoidance Using Belatacept: The CTOT-10 Experience
KA Newell, RB Mannon, AK Mehta, S Tomlanovich, Y Morrison, D Ikle, J Goodman, SG Mehta, N Bridges, P Stock, CP Larsen. Abstract presented at the American Transplant Congress, 2013.
2013 CTOT-01 Multicenter Validation of Urinary Biomarkers in Kidney Transplantation: Urinary CXCL9 Protein Correlates with Acute Rejection and Deterioration of Kidney Function
Donald E Hricik, MD, Peter Nickerson, MD, Richard N Formica, MD, Emilio Poggio, MD, David Rush, MD, Kenneth A Newell, MD, Jens Goebel, MD, Ian W Gibson, MD, Robert Fairchild, PhD, Michael Riggs, David Ikle, Nancy D Bridges, MD, Peter S Heeger, MD. Abstract presented at the American Transplant Congress, 2013.
2013 CTOT-02 Development of De Novo Anti-HLA Abs in Kidney Transplant Recipients: Final Analysis of the NIH CTOT-02 Study
A Chandraker, I Guleria, D Ikle, H Chin, F Vincenti, Y Morrison, N Bridges, W Harmon, M Sayegh. Abstract presented at the American Transplant Congress, 2013.
2014 CTOT-01 Increased expression of matrix remodeling genes during acute rejection
Karen S. Keslar, Peter S. Heeger, Emilio D. Poggio, Robert L. Fairchild, on behalf of the CTOT Consort. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-01 Rabbit ATG Induction Overcomes the Negative Influence of Pre-transplant Memory T Cells on Post-transplant GFR. Results from the CTOT01 Kidney Transplant Trial
D. Hricik, J. Augustine, E. Poggio, R. Fairchild, P. Nickerson, D. Rush, I. Gibson, R.Formica, J. Goebel, K. Newell, D. Ikle, N. Bridges, P. Heeger, and the CTOT-01 Consortium. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-05 Changes in Plasma levels of VEGF-C and Endothelin-1 During the First Post-Transplant Year Are Predictive of Cardiac Allograft Vasculopathy: results from the CTOT-05 Study
Kevin Daly, Randall Starling, Brian Armstrong, David Ikle, Nancy Bridges, Josef Stehlik, Peter Heeger and David M Briscoe. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-05 Correlation of HDL cholesterol efflux with survival and allograft vasculopathy in cardiac transplant recipients
Ali Javaheri, Payman Zamani, Maria Molina, Amrith Rodrigues, Susan Chambers, Patricia Stutman, Wilhelmina Maslanek, Mary Williams, Daniya Lukmanova, Antonino Picataggi, Scott M. Lilly, Jason Christie, Y. Joseph Woo, Peter Heeger, Mohamed Sayegh, Anil Chandraker, Randall Starling, David Briscoe, Kevin Daly, Josef Stehlik, David Ikle, Yvonne Morrison, Nancy Bridges, Lee R. Goldberg, Jeffrey Billheimer, Daniel J. Rader. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-09 Epitope mismatch predicts de novo DSA after CNI withdrawal in low-risk kidney transplant recipients
P Nickerson, C Wiebe, R Formica, K Tinckam, E Poggio, S Bunnaprist, I Gibson, D Rush, M Samaniego, O Gaber, D Ikle, N Bridges, R Fairchild, D Hricik, and P Heeger. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-09 Immune Monitoring and CNI Withdrawal in Low Risk Recipients of Kidney Transplants - Results of CTOT-09
R. Formica, P. Nickerson, E. Poggio, K. Tinckam, S. Bunnaprist, D. Rush, I. Gibson, R. Fairchild, N. Bridges, D. Ikle, D. Hricik, P. Heeger. Abstract presented at the World Transplantation Congress, 2014.
2015 CTOT-08 Validation of a Peripheral Blood Gene Expression Profile for Sub-Clinical Acute Rejection in Kidney Transplant Recipients - findings from the CTOT-08 Study
John Friedewald, Sunil Kurian, Raymond Heilman, Emilio Poggio, Prabhaker Baliga, Kenneth Chavin, Christopher Marsh, David Ikle, Susan Breitgam, Jane Charette, Terri Gelbart, Nancy Bridges, Jonah Odim, Merideth Brown, Daniel R. Salomon, Michael Abecassis. Abstract presented at the American Transplant Congress, 2015.
2015 CTOT-10 Immune Phenotyping of Peripheral Blood Samples from the CTOT-10 Belatacept Study
Yvonne Suessmuth, LA Stempora, B Johnson, Yvonne Morrison, Nancy Bridges, David Ikle, Steve Tomlanovich, Peter Stock, Roslyn Mannon, Kenneth Newell, Christian Larsen, Aneesh K Mehta. Abstract presented at the American Transplant Congress, 2015.
2015 CTOT-01 Urinary biomarkers of renal transplant outcome.
Ho J, Rush DN, Nickerson PW. Curr Opin Organ Transplant. 2015 Aug;20(4):476-81. doi: 10.1097/MOT
This research was performed as part of the Clinical Trials in Organ Transplantation (CTOT) consortium, a collaborative clinical research project headquartered at National Institute of Allergy and Infectious Diseases (NIAID). The work was carried out by members of the CTOT through one or more of the following grants: U01-AI084146 (M. Abecassis), U01-AI063594 (P. Heeger), U01-AI084150 (C. Larsen), U01-AI063623 (M. Sayegh), U01-AI063589 (A. Shaked), U01-AI113315 (S. Palmer), U01-AI113362 (F. Vincenti), U01-AI088635 (D. Iklé) and an American Recovery and Reinvestment Act (ARRA) grant U0163594 (P. Heeger). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy And Infectious Diseases or the National Institutes of Health.



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