Top Image Home Image Title spacer
spacer
spacer
spacer
spacer

Home > Public

Click here to login.  |  spacer
spacer
spacer
spacer
spacer spacer spacer
CTOT Peer-Reviewed Publications

Year Funding Source Publications
2010 ARRA Grant Antibodies Reactive to Non-HLA Antigens in Transplant Glomerulopathy
Rajani Dinavahi, Ajish George, Anne Tretin, Enver Akalin, Scott Ames, Jonathan S. Bromberg, Graciela DeBoccardo, Nicholas DiPaola, Susan M. Lerner, Anita Mehrotra, Barbara T. Murphy, Tibor Nadasdy, Estela Paz Artal, Daniel R. Salomon, Bernd Schröppel, Vinita Sehgal, Ravi Sachidanandam and Peter S. Heeger. Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. Journal of the American Society of Nephrology. 2011 June; 22(6): 1168-1178.
2011 CTOT-01 Anticardiac Myosin Immunity and Chronic Allograft Vasculopathy in Heart Transplant Recipients
S. Kalache, R. Dinavahi, S. Pinney, A Mehrotra, M. Cunningham, P. Heeger. Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. Journal of Immunology. 2011 July 15; 187(2): 1023-1030.
2012 Abecassis Grant The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys.
Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA. Departments of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Proceedings of the National Academy of Science U S A. 2012 April 17; 109(16): 6036-6041
2012 Shaked Grant Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation
Friedman BH, Wolf JH, Wang L, Putt ME, Shaked A, Christie JD, Hancock WW, Olthoff KM. Penn Transplant Institute, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Liver Transplantation. 2012 Feb; 18(2):166-76.
2012 Sayegh Grant Renal interstitial fibrosis: mechanisms and evaluation.
AB Farris, RB Colvin. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA. Current Opinions in Nephrology and Hypertension. 2012 May; 21(3):289-300.
2013 CTOT-03 Gene Set Enrichment Analysis Identifies Key Innate Immune Pathways in Primary Graft Dysfunction After Lung Transplantation
E. Cantu1, D. J. Lederer, K. Meyer, K. Milewski, Y. Suzuki, R. J. Shah, J. M. Diamond, N. J. Meyer, J. W. Tobias, D. A. Baldwin, V. M. Van Deerlin, K. M. Olthoff, A. Shaked, J. D. Christie. Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. American Journal of Transplantation. 2013 Jul; 13(7):1898-904.
2013 ARRA Cellular Working Group Standardization and Cross Validation of Alloreactive IFN? ELISPOT Assays Within the Clinical Trials in Organ Transplantation Consortium
Ashoor I, Najafian N, Korin Y, Reed EF, Mohanakumar T, Ikle D, Heeger PS, Lin M. Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Children's Hospital, Boston, MA. American Journal of Transplantation. 2013 Jul; 13(7):1871-9.
2013 ARRA Molecular Working Group Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling
Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL. Department of Immunology, Cleveland Clinic, Cleveland, OH. American Journal of Transplantation. 2013 Jul; 13(7):1891-7.
2013 ARRA Antibody Working Group Comprehensive Assessment and Standardization of Solid Phase Multiplex-Bead Arrays for the Detection of Antibodies to HLA
Reed EF, Rao P, Zhang Z, Gebel H, Bray RA, Guleria I, Lunz J, Mohanakumar T, Nickerson P, Tambur AR, Zeevi A, Heeger PS, Gjertson D. Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA. American Journal of Transplantation. 2013 Jul; 13(7):1859-70
2013 CTOT-04 Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts
Manikkam Suthanthiran, M.D., Joseph E. Schwartz, Ph.D., Ruchuang Ding, M.D., Michael Abecassis, M.D., Darshana Dadhania, M.D., Benjamin Samstein, M.D., Stuart J. Knechtle, M.D., John Friedewald, M.D., Yolanda T. Becker, M.D., Vijay K. Sharma, Ph.D., Nikki M. Williams, B.S., Christina S. Chang, B.S., Christine Hoang, B.S., Thangamani Muthukumar, M.D., Phyllis August, M.D., M.P.H., Karen S. Keslar, M.S., Robert L. Fairchild, Ph.D., Donald E. Hricik, M.D., Peter S. Heeger, M.D., Leiya Han, M.D., M.P.H., Jun Liu, Ph.D., Michael Riggs, Ph.D., M.P.H., David N. Ikle, Ph.D., Nancy D. Bridges, M.D., and Abraham Shaked, M.D., Ph.D. for the Clinical Trials in Organ Transplantation 04 (CTOT-04) Study Investigators. Weill Cornell Medical College, New York, NY, USA. New England Journal of Medicine 2013 Jul 4; 369(1):20-31.
2013 CTOT-01 Multicenter Validation of Urinary CXCL9 as a Risk-Stratifying Biomarker for Kidney Transplant Injury
D. E. Hricik, P. Nickerson, R. N. Formica, E. D. Poggio, D. Rush, K. A. Newell, J. Goebel, I. W. Gibson, R. L. Fairchild, M. Riggs, K. Spain, D. Ikle, N. D. Bridges, P. S. Heeger, for the CTOT-01 consortium. American Journal of Transplantation, 22 AUG 2013, DOI: 10.1111/ajt.12426.
2014 ARRA Proteomics Working Group Optimization for peptide sample preparation for urine peptidomics
Sigdel TK, Nicora CD, Hsieh SC, Dai H, Qian WJ, Camp DG 2nd, Sarwal MM. Clin Proteomics. 2014 Feb 25;11(1):7.
2015 CTOT-05 Multicenter Analysis of Immune Biomarkers and Heart Transplant Outcomes: Results of the Clinical Trials in Organ Transplantation-05 Study
Starling RC, Stehlik J, Baran D, Armstrong B, Stone JR, Iklé, D, Morrison Y, Bridges, ND, Puthethi P, Strom TB, Bhasin M, Guleria I, Chandraker A, Sayegh M, Daly KP, Briscoe DM, Heeger, PS, and the CTOT-05 consortium. American Journal of Transplantation, 10 AUG 2015, DOI: 10.1111/ajt.13422
2015 CTOT-01 Interferon Gama ELISPOT Testing as a Risk-Stratifying Biomarker for Kidney Transplant Injury: results from the CTOT-01 Multicenter Study
Donald E Hricik, J. Augustine, Peter Nickerson, Richard N Formica, Emilio Poggio, David Rush, Kenneth A Newell, Jens Goebel, Ian W Gibson, Robert Fairchild, Katie Spain, David Ikle, Nancy D Bridges, Peter S Heeger. Am J Transplant. 2015 Dec;15(12):3166-73. doi: 10.1111/ajt.13401. Epub 2015 Jul 30.
2015 CTOT-04 Urine Metabolite P rofiles Predictive of Human Kidney Allograft Status
Karsten Suhre, Joseph E Schwartz, Vijay Sharma, Qiuying Chen, John R Lee, Thangamanai, Darshana M Dadhania, Ruchuange Ding, David Ikle, Nancy D Bridges, Nikki M Williams, Gavi Kastenmuller, Edward D Karoly, Robert P Mohney, Michael Abecassis, John Friedewald, Stuart J Knechtle, Yolanda T Becker, Benjamin Samstein, Abraham Shaked, Steven S Gross, Manikkam Suthanthiran. J Am Soc Nephrol. 2015 Jun 5. pii: ASN.2015010107.
2015 CTOT-09 Adverse Outcomes of Tacrolimus Withdrawal in Immune- Quiescent Kidney Transplant Recipients
Donald E Hricik, Richard N Formica, Peter Nickerson, David Rush, Robert L Fairchild, Emilio Poggio, Ian W Gibson, Chris Wiebe, Kathryn Tinckam, Suphamai Bunnaprist, Milagros Samaniego-Picota, Daniel C Brennan, Bernd Schroppel, Osama Gaber, Brian Armstrong, David Ikle, Helena Diop, Nancy D Bridges, Peter S Heeger (for CTOT-09 consortium). J Am Soc Nephrol. 2015 Dec;26(12):3114-22. doi: 10.1681/ASN.2014121234. Epub 2015 Apr 29.


CTOT Conference Presentations

Year Funding Source Publications
2009 CTOT-01 Early Results From The Clinical Trials In Organ Transplantation (Ctot-01) Trial Identify Noninvasive Markers As Correlates Of 6-Month Renal Allograft Pathology
D Hricik, MD, E Poggio, K Newell, D Rush, P Nickerson, R Formica, E Akalin, J Goebel, R Fairchild, H Gebel, D Ikle and P Heeger and the CTOT-01 Consortium. Abstract presented at the American Transplant Congress, 2009.
2009 CTOT-02
CCTPT-02
Evidence for Immune Activation in Kidney Transplant Recipients Who Develop Post-transplant De Novo Anti-HLA Antibodies: Interim Report of NIH CTOT-02
A Chandraker, B Mfarrej, S De Serres, I Guleria, C Dyer, N Najafian, Y Morrison, N Bridges, D Ikle, W Bennett, A B Cosimi, J Friedewald, A O Gaber, N Goes, B Kaplan, V Kumar,A Olayei, D Norman M Pavlakis, F Weng, P West, F Vincenti and M H Sayegh. Brigham and Women's Hospital & Children’s Hospital Boston, United States. Abstract presented at the American Transplant Congress, 2009.
2009 CTOT-02
CCTPT-02
Evidence for Immune Activation in Kidney Transplant Recipients Who Develop Post-transplant De Novo Anti-HLA Antibodies: Interim Report of NIH CTOT-02
A Chandraker,1S A De Serres, B Mfarrej, I Guleria, C Dyer, N Najafian, Y Morrison, N Bridges, D Ikle, W Bennett, A B Cosimi, J Friedewald, A O Gaber, N Goes, B Kaplan, V Kumar, A Olayei, D Norman, M Pavlakis, F Weng, P West, F Vincenti and M H Sayegh. Transplantation Research Center, Brigham and Women's Hospital, Boston, Harvard Medical School, MA. Poster presented at the American Transplant Congress, 2009.
2009 CTOT-02 Development of De Novo Anti-HLA Antibodies after Transplantation is Associated with Evidence of Systemic Activation of the Immune System: Interim Report of the NIH CTOT-02
A Chandraker, S A De Serres, B Mfarrej, I Guleria, C Dyer, N Najafian, Y Morrison, N Bridges, J Liu, E Norris, W Bennett, A B Cosimi, J Fridewald, A O Gaber, N Goes, B Kaplan, V Kumar, A Olayei, D Norman M Pavlakis, F Weng, P West, F Vincenti, WE Harmon and M H Sayegh.
2010 CTOT-04 Validation of Urinary Cell Biomolecular Markers of Acute Cellular Rejection: A Report from CTOT-4 Trial Investigators.
M. Suthanthiran, R. Ding, V. Sharma, M. Abecassis, D. Dadhania, B. Samstein, S. Knechtle, W. Hancock, J. Schwartz, J. Liu, N. Bridges, A. Shaked and the CTOT-04 Investigators. Abstract presented at the American Transplant Congress, 2010.
2010 CTOT-02
CCTPT-02
Silent development of de novo anti HLA antibodies following transplantation is associated with histological changes in the allograft. Interim report on behalf of the CTOT-02/CCTPT-02 study.
Sacha A De Serres, MD, Bechara G Mfarrej, Indira Guleria, PhD, Nader Najafian, MD, Yvonne R Morrison, Flavio G. Vincenti, MD, William E. Harmon, MD, Mohamed H. Sayegh, MD, FASN and Anil Chandraker, MBChB, FASN. Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA, United States; 2UCSF, San Francisco, CA and 3NIH/NIAID/DAIT, Bethesda, MD. Abstract presented at the American Society for Nephrology Kidney Week, 2010.
2010 CTOT-01 Cellular Or Humoral Sensitization Increases The Risk Of Delayed Graft Function And Acute Rejection In Recipients Of Expanded Criteria Donor Kidneys.
Donald E. Hricik, MD, Joshua J. Augustine, MD, Aparna Padiyar, MD and Peter S. Heeger, MD. University Hospitals Case Medical Center, Cleveland, Ohio, and Mt. Sinai School of Medicine, New York, New York, United States. Abstract presented at ASN Kidney Week, 2010.
2011 CTOT-04 Urinary Cell Messenger RNA Expression Signatures Anticipate Acute Cellular Rejection: A Report from CTOT-04
Suthanthiran M, Ding R, Sharma V, Abecassis M, Dadhania D, Samstein B, Knechtle S, Hancock W, Han L, Schwartz J, Liu J, Bridges N, Shaked A. Abstract presented at the American Transplant Congress, 2011.
2011 CTOT-02
CCTPT-02
Development of circulating anti-HLA antibodies is associated with acute rejection: Interim Analysis of CTOT02
SA De Serres, BG Mfarrej, I Guleria, N Najafian, D Ikle, FG Vincenti WE Harmon, MH Sayegh, and A Chandraker. Abstract presented at ASN Kidney Week, 2011.
2011 CTOT-05 Incidence of Coronary Artery Vasculopathy Has Decreased with Modern Immunosuppression: Insights from Clinical Trials in Organ Transplantation
R.C. Starling, J. Stehlik, S. Nicholls, D. Ikle, A. Chandraker, F. Teresa, D. Baran, K. Wolski, B. Mfarrej, U. Ahmad, M. Sayegh, P. Heeger. Poster presented at the Annual Meeting of the ISHLT, 2011.
2011 CTOT Immune Alteration in Stable Renal Allograft Recipients Treated with Belatacept
PW Thompson; AK Mehta; LA Stempora; J Cheeseman; J Joseph; B Begley; E Ferry; S Thomas; AD Kirk; K Newell; CP Larsen. Poster presented at the Annual Meeting of The Transplantation Society, 2011.
2012 CTOT-02
CCTPT-02
In Vitro C1q Binding is Associated with Acute Rejection Among Renal Transplant Recipients Who Develop Circulating Anti-HLA Antibodies: Preliminary Analysis of the NIH CTOT02.
A Chandraker, S De Serres, U Ahmad, B Mfarrej, I Guleria, N Najafian, D Ikle, H Chin, F G Vincenti, W E Harmon and M H Sayegh. Abstract presented at the American Transplant Congress, 2012.
2012 ARRA Antibody Working Group Validation of the luminex platform to detect and quantify anti-HLA antibodies: Assessment of Manufacture variability by 7 CTOT core laboratories.
E.Reed, P. Rao, Z. Zhang, H. Gebel, I. Guleria, T. Monanakumar, P. Nickerson, A. Tambur, A. Zeevi, D. Gjertson, P. Heeger and the CTOT Core Antibody Testing Laboratories. Abstract presented at the American Transplant Congress, 2012.
2012 ARRA Antibody Working Group Validation of the Luminex platform to detect and quantify anti-HLA antibodies: Consistency in median florescence intensity (MFI) among 7 CTOT core laboratories.
E Reed, P Rao, Z Zhang, H Gebel, I Guleria, T Mohanakumar, P Nickerson, A Tambur, A Zeevi, D Gjertson, P. Heeger and the CTOT Core Antibody Testing Laboratories. Abstract presented at the American Transplant Congress, 2012.
2012 CTOT Comparison of Viral Immunity in Stable Renal Allograft Recipients Treated with Belatacept or Tacrolimus
Yvonne Suessmuth PhD, PW Thompson; C Breeden; B Johnson; R Jones; LA Stempora; J Cheeseman; J Joseph; B Begley; S Thomas; AD Kirk; K Newell; CP Larsen; AK Mehta. Abstract presented at the American Transplant Congress, 2012.
2012 ARRA Antibody Working Group Validation of the Luminex platform to detect and quantify HLA antibodies: Effect of standardizing operation procedures on test variability by CTOT core laboratories
Rao P, Zhang Z., Gebel H., Bray R., Guleria I., Monanakumar T., Nickerson P., Tambur A., Zeevi A., Heeger P., Gjertson D, Reed E and the Clinical Trials in Organ Transplantation Core Antibody Testing Laboratories.
2012 ARRA Antibody Working Group Cross validation of Luminex platforms from two vendors to detect and quantify HLA antibodies using single antigen assay results from 7 CTOT core laboratories.
E.Reed, P. Rao, Z. Zhang, H. Gebel, R. Bray, I. Guleria, T. Monanakumar, P. Nickerson, A. Tambur, A. Zeevi, P. Heeger, D. Gjertson and the Clinical Trials in Organ Transplantation Core Antibody Testing Laboratories. Abstract presented at the Annual Meeting of The Transplantation Society, 2012.
2013 CTOT-10 Comparison of Baseline and Day 28 Post Transplant Renal Allograft Samples for the CTOT-10 Belatacept Study
Y Suessmuth, L A Stempora, B Johnson, J Cheeseman, Y Morrison, N Bridges, D Ikle, S Tomlanovich, P Stock, R Mannon, K Newell, C P Larsen, AK Mehta. Abstract presented at the American Transplant Congress, 2013.
2013 CCTPT-02/ CTOT-02 Children Develop De Novo Anti-HLA Antibodies (Abs) following kidney transplantation at a higher incidence than adults: An Analysis of the NIH CTOT/CCTPT-02 study.
W Harmon, MD, I Guleria, PhD, D Ikle, PhD, B Armstrong, MPH, L Spaneas, RN, MPH, Y Morrison, N Bridges, MD, M Sayegh, MD, A Chandraker, MD. Abstract presented at the American Transplant Congress, 2013.
2013 CTOT-10 Long Term Calcineurin (CNI) and Corticosteroids (CS) Avoidance Using Belatacept: The CTOT-10 Experience
KA Newell, RB Mannon, AK Mehta, S Tomlanovich, Y Morrison, D Ikle, J Goodman, SG Mehta, N Bridges, P Stock, CP Larsen. Abstract presented at the American Transplant Congress, 2013.
2013 CTOT-01 Multicenter Validation of Urinary Biomarkers in Kidney Transplantation: Urinary CXCL9 Protein Correlates with Acute Rejection and Deterioration of Kidney Function
Donald E Hricik, MD, Peter Nickerson, MD, Richard N Formica, MD, Emilio Poggio, MD, David Rush, MD, Kenneth A Newell, MD, Jens Goebel, MD, Ian W Gibson, MD, Robert Fairchild, PhD, Michael Riggs, David Ikle, Nancy D Bridges, MD, Peter S Heeger, MD. Abstract presented at the American Transplant Congress, 2013.
2013 CTOT-02 Development of De Novo Anti-HLA Abs in Kidney Transplant Recipients: Final Analysis of the NIH CTOT-02 Study
A Chandraker, I Guleria, D Ikle, H Chin, F Vincenti, Y Morrison, N Bridges, W Harmon, M Sayegh. Abstract presented at the American Transplant Congress, 2013.
2014 CTOT-01 Increased expression of matrix remodeling genes during acute rejection
Karen S. Keslar, Peter S. Heeger, Emilio D. Poggio, Robert L. Fairchild, on behalf of the CTOT Consort. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-01 Rabbit ATG Induction Overcomes the Negative Influence of Pre-transplant Memory T Cells on Post-transplant GFR. Results from the CTOT01 Kidney Transplant Trial
D. Hricik, J. Augustine, E. Poggio, R. Fairchild, P. Nickerson, D. Rush, I. Gibson, R.Formica, J. Goebel, K. Newell, D. Ikle, N. Bridges, P. Heeger, and the CTOT-01 Consortium. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-05 Changes in Plasma levels of VEGF-C and Endothelin-1 During the First Post-Transplant Year Are Predictive of Cardiac Allograft Vasculopathy: results from the CTOT-05 Study
Kevin Daly, Randall Starling, Brian Armstrong, David Ikle, Nancy Bridges, Josef Stehlik, Peter Heeger and David M Briscoe. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-05 Correlation of HDL cholesterol efflux with survival and allograft vasculopathy in cardiac transplant recipients
Ali Javaheri, Payman Zamani, Maria Molina, Amrith Rodrigues, Susan Chambers, Patricia Stutman, Wilhelmina Maslanek, Mary Williams, Daniya Lukmanova, Antonino Picataggi, Scott M. Lilly, Jason Christie, Y. Joseph Woo, Peter Heeger, Mohamed Sayegh, Anil Chandraker, Randall Starling, David Briscoe, Kevin Daly, Josef Stehlik, David Ikle, Yvonne Morrison, Nancy Bridges, Lee R. Goldberg, Jeffrey Billheimer, Daniel J. Rader. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-09 Epitope mismatch predicts de novo DSA after CNI withdrawal in low-risk kidney transplant recipients
P Nickerson, C Wiebe, R Formica, K Tinckam, E Poggio, S Bunnaprist, I Gibson, D Rush, M Samaniego, O Gaber, D Ikle, N Bridges, R Fairchild, D Hricik, and P Heeger. Abstract presented at the World Transplantation Congress, 2014.
2014 CTOT-09 Immune Monitoring and CNI Withdrawal in Low Risk Recipients of Kidney Transplants - Results of CTOT-09
R. Formica, P. Nickerson, E. Poggio, K. Tinckam, S. Bunnaprist, D. Rush, I. Gibson, R. Fairchild, N. Bridges, D. Ikle, D. Hricik, P. Heeger. Abstract presented at the World Transplantation Congress, 2014.
2015 CTOT-08 Validation of a Peripheral Blood Gene Expression Profile for Sub-Clinical Acute Rejection in Kidney Transplant Recipients - findings from the CTOT-08 Study
John Friedewald, Sunil Kurian, Raymond Heilman, Emilio Poggio, Prabhaker Baliga, Kenneth Chavin, Christopher Marsh, David Ikle, Susan Breitgam, Jane Charette, Terri Gelbart, Nancy Bridges, Jonah Odim, Merideth Brown, Daniel R. Salomon, Michael Abecassis. Abstract presented at the American Transplant Congress, 2015.
2015 CTOT-10 Immune Phenotyping of Peripheral Blood Samples from the CTOT-10 Belatacept Study
Yvonne Suessmuth, LA Stempora, B Johnson, Yvonne Morrison, Nancy Bridges, David Ikle, Steve Tomlanovich, Peter Stock, Roslyn Mannon, Kenneth Newell, Christian Larsen, Aneesh K Mehta. Abstract presented at the American Transplant Congress, 2015.
2015 CTOT-01 Urinary biomarkers of renal transplant outcome.
Ho J, Rush DN, Nickerson PW. Curr Opin Organ Transplant. 2015 Aug;20(4):476-81. doi: 10.1097/MOT
This research was performed as part of the Clinical Trials in Organ Transplantation (CTOT) consortium, a collaborative clinical research project headquartered at National Institute of Allergy and Infectious Diseases (NIAID). The work was carried out by members of the CTOT through one or more of the following grants: U01-AI084146 (M. Abecassis), U01-AI063594 (P. Heeger), U01-AI084150 (C. Larsen), U01-AI063623 (M. Sayegh), U01-AI063589 (A. Shaked), U01-AI113315 (S. Palmer), U01-AI113362 (F. Vincenti), U01-AI088635 (D. Iklé) and an American Recovery and Reinvestment Act (ARRA) grant U0163594 (P. Heeger). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy And Infectious Diseases or the National Institutes of Health.



spacer

spacer